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A few population-based cohort studies have confirmed that a decrease in the ABI is highly correlated with an increase in the prevalence rate of coronary artery disease and cerebrovascular disease. A low ABI is related to many known cardiovascular risk factors, including hypertension, diabetes, smoking, dyslipidemia, obesity, and increased serum levels of C-reactive protein.
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In diabetic patients, PAD can be noninvasively and objectively diagnosed by using the ankle-brachial index (ABI) this index can also indicate arterial atherosclerosis at other sites. Lower extremity peripheral arterial disease (PAD) is a common type of PAD in patients with type 2 diabetes mellitus (T2DM). Introductionĭiabetes patients with peripheral arterial disease (PAD) are at an increased risk for cardiovascular disease. In conclusion, lower extremity PAD increased coronary heart disease and stroke risks in T2DM. Compared with those in the T2DM non-PAD group, the odds ratios (ORs) for CHD and stroke risk were 3.6 (95% confidence interval (CI), 2.2–6.0 ) and 6.9 (95% CI, 4.0–11.8 ) in those with lower extremity PAD, respectively. Logistic stepwise regression analysis indicated that ABI was an independent predictor of 10-year CHD and stroke risks in T2DM patients. Age duration of diabetes systolic blood pressure the hypertension rate the use of hypertension drugs, ACEI /ARB, and statins CHD risk fatal CHD risk stroke risk and fatal stroke risk were significantly higher in the PAD group than in the non-PAD group ( for all). The patients were divided into a lower extremity PAD group (ankle-brachial or >1.4 88 patients, 7.5%) and a non-PAD group (ankle-brachial and ≤1.4 1090 patients, 92.5%). We enrolled 1178 hospitalized T2DM patients. We aimed to determine the relationship between lower extremity peripheral arterial disease (PAD), 10-year coronary heart disease (CHD), and stroke risks in patients with type 2 diabetes (T2DM) using the UKPDS risk engine.